Optical Imaging of Human Brain Activity

As highlighted by the NIH Brain Initiative, the field of neuroscience is undergoing a technological revolution with new optical methods to both manipulate and record neural activity with single cell resolution. However, rarely have these advances been adapted to the clinic or operating room to facilitate the diagnosis and treatment of human brain disease. We are beginning to develop the key technologies for establishing two-photon microscopy as a safe and viable clinical and translational tool for studying human brain function.