Matthew Shtrahman
Principal Investigator
Matt received his undergraduate degree in Biochemistry from the University of Michigan. He returned to his hometown to obtain his MD and PhD degrees at the University of Pittsburgh, where he did his thesis work with Dr. Xiao-lun Wu in the Department of Physics. He completed his residency training and clinical neurophysiology fellowship in the Department of Neurology at UCLA. Matt went on to do his postdoctoral training in the labs of Dr. Tom Otis at UCLA and Dr. Fred Gage at the Salk Institute before joining the faculty of the Department of Neurosciences at UCSD in 2016.
Daniel Enterria-Morales
Postdoctoral Fellow
Samir Saidi
Ph.D. Student
Samir is a PhD student in the UCSD Bioengineering Department. He is mainly interested in designing new optical tools to study the brain in vivo. When not in the lab, Samir enjoys training for marathons and attempting to surf.
Matisse Willardson
Lab Technician and Manager
Adrian graduated from UCSD with a B.S. in Cognitive & Behavioral Neuroscience. He is interested in many areas of Neuroscience spanning from cellular to systems. Adrian is currently investigating mesial temporal lobe epilepsy, glioblastoma, and AAV. He plans on pursuing a Ph.D. in Neuroscience. When not in lab, Adrian enjoys backpacking, cooking, and learning about new tech.
Cris Sharp
R&D Engineer
Volunteers
Emeen Al-Delaimy
Rebecca Ha
Jamie Hur
Kristen Kawashima
Vidisha Marwaha
Monica Jensen
Srija Pamujula
Robert Parsons
Robert is an undergraduate at UCSD completing a B.S. in Cognitive Science with a specialization in Neuroscience. He is interested in researching neurological and behavioral illnesses with a focus on Alzheimer’s and Parkinson’s disease. Robert is currently investigating AAV-induced ablation of neurogenesis and really enjoys studying interactions between neural progenitor cells and viruses. He aspires to become a Ph.D. student to further his interests in said research. In his free time, Robert, enjoys playing tennis, chess, bouldering, and rock climbing.
Janine Rho
Amanda Sirisoma
Nolan Soutipan
Kristian Maniti
Brandon Tse
Tomosuke Yamaguchi
Alumni
Summer Batasin Dev Bhatia Cooper Bloyd – Currently a medical student at UC San Francisco School of Medicine. Derek Cai – Currently at Twist Biosciences. Achol Chowdhury Bryan Ha Shannon Kee – Currently a medical student at UT Health San Antonio. Stacy Kim – Currently a PhD student in the department of Cognitive Science at UCSD. Nolan Mac Alexandr Newberry Joseph Newhide Dennis Ren – Currently an Electrical Engineer at Freeform. Bryan Ryba – Currently a resident physician in Neurological Surgery at UCSD. Clyde Sanvictores Sharon Sengphanith – Currently at BioLegend. Prithvi Setty Lauren Stiene Shuhe Wang – Currently a SRA at UCSD in the lab of Dr. Jong Rho. Emily Yan – Currently a medical student at Dell Medical School, UT Austin. Tammy Zhou
Publications
Stephen Johnston, Sarah L Parylak, Stacy Kim, Nolan Mac, Christina Lim, Iryna Gallina, Cooper Bloyd, Alexander Newberry, Christian D Saavedra, Ondrej Novak, J Tiago Gonçalves, Fred H Gage, Matthew Shtrahman. AAV ablates neurogenesis in the adult murine hippocampus. eLife 2021;10:e59291. PDF
Tristan Shuman, Daniel Aharoni, Denise J. Cai, Christopher R. Lee, Spyridon Chavlis, Lucia Page-Harley, Lauren M. Vetere, Yu Feng, Chen Yi Yang, Irene Mollinedo-Gajate, Lingxuan Chen, Zachary T. Pennington, Jiannis Taxidis, Sergio E. Flores, Kevin Cheng, Milad Javaherian, Christina C. Kaba, Naina Rao, Mimi La-Vu, Ioanna Pandi, Matthew Shtrahman, Konstantin I. Bakhurin, Sotiris C. Masmanidis, Baljit S. Khakh, Panayiota Poirazi, Alcino J. Silva & Peyman Golshani. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci 23, 229–238 (2020). PMID: 31907437. PDF
ST Johnston, SL Parylak, S Kim, N Mac, CK Lim, IS Gallina, CW Bloyd, A Newberry, CD Saavedra, O Novák, JT Gonçalves, FH Gage, M Shtrahman. AAV Ablates Neurogenesis in the Adult Murine Hippocampus. bioRxiv 2020.01.18.911362. PDF
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016; 14(1):40. PMID: 27197636. PDF
Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage FH. In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 Jun; 19(6):788-91. PMID: 27135217. PDF
Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage FH. Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Neurobiol Learn Mem. 2016 Mar; 129:60-8. PMID: 26549627. PDF
Shtrahman M, Aharoni DB, Hardy NF, Buonomano DV, Arisaka K, Otis TS. Multifocal fluorescence microscope for fast optical recordings of neuronal action potentials. Biophys J. 2015 Feb 3; 108(3):520-9. PMID: 25650920. PDF
Mostany R, Miquelajauregui A, Shtrahman M, Portera-Cailliau C. Two-photon excitation microscopy and its applications in neuroscience. Methods Mol Biol. 2015; 1251:25-42. PMID: 25391792. PDF
Yeung C, Shtrahman M, Wu XL. Stick-and-diffuse and caged diffusion: a comparison of two models of synaptic vesicle dynamics. Biophys J. 2007 Apr 1; 92(7):2271-80. PMID: 17218458. PDF
Shtrahman M, Yeung C, Nauen DW, Bi GQ, Wu XL. Probing vesicle dynamics in single hippocampal synapses. Biophys J. 2005 Nov; 89(5):3615-27. PMID: 16113110. PDF
Funding
Our research would not be possible without funding from the following sources:
Shtrahman Lab 