Matthew Shtrahman
Principal Investigator

Matthew Shtrahman Profile Photo

Matt received his undergraduate degree in Biochemistry from the University of Michigan. He returned to his hometown to obtain his MD and PhD degrees at the University of Pittsburgh, where he did his thesis work with Dr. Xiao-lun Wu in the Department of Physics. He completed his residency training and clinical neurophysiology fellowship in the Department of Neurology at UCLA. Matt went on to do his postdoctoral training in the labs of Dr. Tom Otis at UCLA and Dr. Fred Gage at the Salk Institute before joining the faculty of the Department of Neurosciences at UCSD in 2016.

 

Johanna Gesperger
Postdoctoral Fellow

mouse-1.jpg

 

 

Samir Saidi
Ph.D. Student

Matthew Shtrahman Portraits - December 8, 2016

Samir is a PhD student in the UCSD Bioengineering Department. He is mainly interested in designing new optical tools to study the brain in vivo. When not in the lab, Samir enjoys training for marathons and attempting to surf.

 

 

Adrian Martinez
Research Assistant

adrianfinal2-1.jpg

Adrian graduated from UCSD with a B.S. in Cognitive & Behavioral Neuroscience. He is interested in many areas of Neuroscience spanning from cellular to systems. Adrian is currently investigating mesial temporal lobe epilepsy, glioblastoma, and AAV. He plans on pursuing a Ph.D. in Neuroscience. When not in lab, Adrian enjoys backpacking, cooking, and learning about new tech.

Cris Sharp
R&D Engineer

cris-sharp_180x225.jpg

 

 

 

 

 

 

 

Volunteers

Emeen Al-Delaimy

mouse-1.jpg

 

 

Rebecca Ha

mouse-1.jpg

 

 

Jamie Hur

mouse-1.jpg

 

 

Kristen Kawashima

kristen-kawashima.jpg

 

 

Vidisha Marwaha

mouse-1.jpg

 

 

Avani Mylvara

mouse-1.jpg

 

 

Srija Pamujula

srija-pamujula.jpg

 

 

Robert Parsons

robert-parsons.jpg

Robert is an undergraduate at UCSD completing a B.S. in Cognitive Science with a specialization in Neuroscience. He is interested in researching neurological and behavioral illnesses with a focus on Alzheimer’s and Parkinson’s disease. Robert is currently investigating AAV-induced ablation of neurogenesis and really enjoys studying interactions between neural progenitor cells and viruses. He aspires to become a Ph.D. student to further his interests in said research. In his free time, Robert, enjoys playing tennis, chess, bouldering, and rock climbing.

Janine Rho

mouse-1.jpg

 

 

Amanda Sirisoma

mouse-1.jpg

 

 

Nolan Soutipan

nolan-soutipan-1.jpg

 

 

Nicolaas Ugalde

mouse-1.jpg

 

 

Qianxun Wang

mouse-1.jpg

 

 

Tomosuke Yamaguchi

mouse-1.jpg

 

 

 

 

 

 

Alumni

Summer Batasin

Dev Bhatia

Cooper Bloyd – Currently a medical student at UC San Francisco School of Medicine.

Derek Cai – Currently at Twist Biosciences.

Achol Chowdhury

Bryan Ha

Shannon Kee – Currently a medical student at UT Health San Antonio.

Stacy Kim – Currently a PhD student in the department of Cognitive Science at UCSD.

Nolan Mac

Alexandr Newberry

Joseph Newhide

Dennis Ren – Currently an Electrical Engineer at Freeform.

Bryan Ryba – Currently a resident physician in Neurological Surgery at UCSD.

Clyde Sanvictores

Sharon Sengphanith – Currently at BioLegend.

Prithvi Setty

Lauren Stiene

Shuhe Wang – Currently a SRA at UCSD in the lab of Dr. Jong Rho.

Emily Yan – Currently a medical student at Dell Medical School, UT Austin.

Tammy Zhou

 

 

 

Publications

Stephen Johnston, Sarah L Parylak, Stacy Kim, Nolan Mac, Christina Lim, Iryna Gallina, Cooper Bloyd, Alexander Newberry, Christian D Saavedra, Ondrej Novak, J Tiago Gonçalves, Fred H Gage, Matthew Shtrahman. AAV ablates neurogenesis in the adult murine hippocampus. eLife 2021;10:e59291. PDF

Tristan Shuman, Daniel Aharoni, Denise J. Cai, Christopher R. Lee, Spyridon Chavlis, Lucia Page-Harley, Lauren M. Vetere, Yu Feng, Chen Yi Yang, Irene Mollinedo-Gajate, Lingxuan Chen, Zachary T. Pennington, Jiannis Taxidis, Sergio E. Flores, Kevin Cheng, Milad Javaherian, Christina C. Kaba, Naina Rao, Mimi La-Vu, Ioanna Pandi, Matthew Shtrahman, Konstantin I. Bakhurin, Sotiris C. Masmanidis, Baljit S. Khakh, Panayiota Poirazi, Alcino J. Silva & Peyman Golshani. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci 23, 229–238 (2020). PMID: 31907437. PDF

ST Johnston, SL Parylak, S Kim, N Mac, CK Lim, IS Gallina, CW Bloyd, A Newberry, CD Saavedra, O Novák, JT Gonçalves, FH Gage, M Shtrahman. AAV Ablates Neurogenesis in the Adult Murine Hippocampus. bioRxiv 2020.01.18.911362. PDF

Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016; 14(1):40. PMID: 27197636. PDF

Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage FH. In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 Jun; 19(6):788-91. PMID: 27135217. PDF

Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage FH. Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Neurobiol Learn Mem. 2016 Mar; 129:60-8. PMID: 26549627. PDF

Shtrahman M, Aharoni DB, Hardy NF, Buonomano DV, Arisaka K, Otis TS. Multifocal fluorescence microscope for fast optical recordings of neuronal action potentials. Biophys J. 2015 Feb 3; 108(3):520-9. PMID: 25650920. PDF

Mostany R, Miquelajauregui A, Shtrahman M, Portera-Cailliau C. Two-photon excitation microscopy and its applications in neuroscience. Methods Mol Biol. 2015; 1251:25-42. PMID: 25391792. PDF

Yeung C, Shtrahman M, Wu XL. Stick-and-diffuse and caged diffusion: a comparison of two models of synaptic vesicle dynamics. Biophys J. 2007 Apr 1; 92(7):2271-80. PMID: 17218458. PDF

Shtrahman M, Yeung C, Nauen DW, Bi GQ, Wu XL. Probing vesicle dynamics in single hippocampal synapses. Biophys J. 2005 Nov; 89(5):3615-27. PMID: 16113110. PDF

 

 

 

Funding

Our research would not be possible without funding from the following sources:

CBAM

ACTRI-logo_b